Model based-monitoring of a non-uniform batch in a freeze-drying process
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چکیده
This paper deals with the freeze-drying of pharmaceuticals in vials and assesses the importance of model-based monitoring of the process; in fact, the vials in the chamber of the freeze-drier can exhibit different behaviors due to radiation effects and fluiddynamics as it has been evidenced by CFD simulations. The curves obtained by traditional Pressure Rise Test (PRT) provide mean values of the parameters of the batch and thus can be misleading. To this purpose a new monitoring tool is proposed.
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تاریخ انتشار 2008